Events relating to the medici
Hippocrates, on the Greek island of Kos, founds an influential school of medicine
The Alexandrian school of medicine develops an alarming form of clinical anatomy – human vivisection
The practice of acupuncture is described in Nei Qing, a Chinese medical text
The Roman surgeon Cornelius Celsus describes in De Medicina how to cut stones from a patient's bladder
The Persian scholar Avicenna, author of encyclopedic works on philosophy and medicine, spends the last part of his life in Isfahan
The Medici move into Florence from their country home in the Mugello valley
Cosimo de' Medici, arrested by a rival faction, escapes with his life thanks to bribes and well-placed friends
In keeping with his personal interest in Plato, Cosimo de' Medici founds a Platonic Academy in Florence
After his death in 1464, Cosimo de' Medici acquires the posthumous title pater patriae – father of the fatherland

Sandro Botticelli is established as one of the leading painters of Florence, working in particular for the Medici
Tommaso Portinari, the Medici agent in Bruges, commissions an altarpiece from Hugo van der Goes for his family church in Florence
A plot by the Pazzi family, with papal connivance, results in the murder of Guiliano de' Medici during high mass in Florence's cathedral
Botticelli paints the Birth of Venus and Spring for the villa of a Medici cousin of Lorenzo the Magnificent
Leonardo da Vinci begins an unprecedented series of detailed anatomical drawings, based on corpses dissected in Rome

Savonarola, the new prior of San Marco, is a stern critic of both the pope in Rome and the Medici in Florence
Piero de' Medici and his brothers flee from Florence, after a mob ransacks the Medici palace
European diseases bring death on a massive scale to an American population that has no immunity
Tobacco is grown in Europe's physic gardens for its medicinal qualities
Soft-paste porcelain, in imitation of true porcelain from China, is successfully created for the Medici in Florence
William Harvey publishes a short book, De Motu Cordis, proving the circulation of the blood
Samuel Pepys has a two-ounce stone cut from his bladder, in an operation carried out at home in the presence of his family
The first recorded attempt at blood transfusion, at the Royal Society in London, proves that the idea is feasible
Florence loses her independence when the last Medici duke of Tuscany dies
English obstetrician William Smellie introduces scientific midwifery as a result of his researches into childbirth
Captain Cook publishes his discovery of a preventive cure against scurvy, in the form of a regular ration of lemon juice