Events relating to europe
Francisco Pizarro sails from Panama to attempt the conquest of Peru
Charles V gives Malta to the Knights of St John at an annual rental of one falcon
Francisco Pizarro leads 168 men, with about 30 horses, into the territory of the Inca empire
François Rabelais publishes Pantagruel, the first to appear of his five books about the giant Pantagruel and his father Gargantua
Pizarro and his tiny force ambush and massacre the Inca court in Cajamarca, capturing Atahualpa himself alive
Atahualpa agrees to buy his freedom from the Spaniards with a room full of gold and another of silver
Although the ransom has been paid, Atahualpa is executed by the Spaniards — who ensure that he dies a Christian
The Spanish conquistadors capture and sack the Inca capital of Cuzco, high in the Andes
Thomas Cranmer, the archbishop of Canterbury, declares Henry VIII's marriage to Catherine of Aragon null and void
Anne Boleyn has a child (the future Elizabeth I) but not of the sex her husband wants
The Holy Roman Emperor, Charles V, makes Titian his court painter (an arrangement continued by Philip II)
Henry VIII's Act of Supremacy forces prominent figures in English public life to accept him on oath as head of the Church of England
The Portuguese force the local ruler to cede to them the island of Bombay
Paris wakes up to find Protestant placards all over the place, mocking the sacrament of the mass

Thomas More refuses to take the oath accepting the Act of Supremacy and is beheaded

Henry VIII begins the process of gathering in the wealth of England's monasteries
Wales is merged within the English kingdom as a principality
Christian III seizes the wealth of Danish churches and monasteries, before turning his attention to those of Norway
Manco Inca begins a siege of the Spaniards in Cuzco that lasts for a year
The reign of Christian III begins three centuries in which Norway is administered as little more than an annexe of Denmark
Henry VIII's queen, Anne Boleyn, is beheaded in the Tower of London on unsubstantiated charges of adultery
With the end of the siege of Cuzco, and the flight of Manco Inca, the Spanish have full control of Peru
Jane Seymour gives birth to Henry VIII's long-awaited male heir (the future Edward VI)
Jane Seymour dies twelve days after giving birth to Henry VIII's heir, the future Edward VI
The Great Bible, commissioned by Henry VIII for use in every Anglican church, is published