Events relating to europe
Raphael begins work on the frescoes in the pope's apartment in the Vatican, known as the Stanze ('Rooms')

On the death of his father, and as the result of the death of his elder brother Arthur, Henry VIII becomes king of England
Erasmus and Thomas More take the northern Renaissance in the direction of Christian humanism
Giorgione and Titian introduce the richness of colour which characterizes the high Renaissance style in Venice
The Portuguese seize Goa and make it their colonial capital in India
The startling colour contrasts in Michelangelo's Sistine ceiling anticipate one of the main characteristics of Italian mannerism

The painter Giorgione dies after a short but extremely influential life in Venice
The earliest surviving curling stone, discovered in Scotland, dates from this year
The Portuguese take control of Malacca, in the Malay peninsula, as a base for trade further east
The Portuguese make treaties in the Moluccas (or Spice Islands), to trade in cloves and nutmeg
James IV of Scotland dies at Flodden, in the disastrous defeat of his army by the English
Vasco Núñez de Balboa reaches the Pacific coast and claims the ocean for the king of Spain
On the death of his father at Flodden, the one-year-old James V becomes king of Scotland
The Portuguese capture Hormuz and establish a garrison to control the Gulf of Oman
Louis XII is succeeded on the French throne by his cousin and son-in-law, Francis I
The king of France, Francis I, wins a dramatic victory at Marignano and captures Milan
The Spanish complete the conquest of Cuba and establish the town of Havana
The death of Ferdinand II results in Spain becoming part of the Habsburg empire, under the rule of Charles V (as Charles I of Spain)
Catherine of Aragon gives birth to a daughter, Mary, who becomes the only one of her six children to live beyond infancy
The original ghetto is established as a district to which the Jews of Venice are confined
Ariosto, in Orlando Furioso, tells of Roland's madness when he is abandoned by the pagan princess Angelica
Erasmus publishes an influential edition of the New Testament in its original Greek
From Bosnia to Egypt and Arabia, the Ottoman Turks now rule the largest Muslim empire since the early caliphate - and will frequently use the title of caliph to assert their authority within Sunni Islam
Leonardo da Vinci moves to France, on the invitation of Francis I
The Spanish conquistador Hernando Cortes lands on the coast of Mexico with 600 men, 16 horses and about 20 guns