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| | | | World History timeline |
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| 1494 |
| | | Charles VIII, king of France, marches through the Alps with an army of 30,000, to claim the throne of Naples | |
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| 1494 |
| | | Piero de' Medici and his brothers flee from Florence, after a mob ransacks the Medici palace | |
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| 1495 |
| | | Charles VIII captures Naples in February and is crowned there in May, but is forced back across the Alps before the end of the year | |
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| c. 1495 |
| | | Dürer, the first great artist to tackle the complexities of printing, becomes a master of woodcut and engraving | |
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| c. 1495 |
| | | The type faces known as roman and italic are created in Venice by the printers Nicolas Jenson and Aldus Manutius | |
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| 1496 |
| | | Diego Columbus, brother of the explorer, establishes the first secure Spanish colony at Santo Domingo | |
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| 1496 |
| | | Philip, heir to Austria, marries Joanna, a daughter of Ferdinand and Isabella of Spain, in the second of the great Habsburg marital alliances | |
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| 1497 |
| | | Savonarola, in the carnival before Lent, urges the people of Florence to throw playing cards and lewd images on a great bonfire of vanities | |
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| 1497 |
| | | Henry VII commissions the Italian navigator John Cabot to cross the Atlantic in search of new territories for England | |
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| 1497 |
| | | John Cabot, searching for a trade route to China, probably reaches Newfoundland | |
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| 1498 |
| | | The Florentine mob, weary of puritanism, attacks the convent of San Marco and drags Savonarola away to be hanged and burnt | |
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| 1498 |
| | | Vasco da Gama reaches the southern coast of India, at Calicut, after sailing across the Indian Ocean from east Africa | |
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| 1499 |
| | | 24-year-old Michelangelo provides for St Peter's in Rome an exquisite Pietà – the Virgin holding on her lap the dead Christ | |
|  | Pietà Michelangelo
Fotofile CG
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| 1499 |
| | | The Swiss (or Swabian) War ends with the treaty of Basel, bringing effective recognition of Swiss independence from the Habsburg empire | |
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| 1499 |
| | | After three feeble attempts to invade England, Perkin Warbeck is captured by Henry VII (in 1497) and is hanged at Tyburn | |
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| c. 1500 |
| | | The people of Benin begin a lasting tradition of sculpture in brass, melted down from objects brought by traders | |
|  | Nigerian Bronze Head, 16th century
British Museum
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| c. 1500 |
| | | The lively realism of Kamal-ud-din Bihzad lays the basis of both the Persian and the Mughal schools of painting | |
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| c. 1500 |
| | | Even the remote city of Machu Picchu, on its peak above the jungle, is built in the massively precise Inca style of masonry | |
|  | Machu Picchu
Photograph Josceline Dimbleby
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| c. 1500 |
| | | The first etchings are printed in Augsburg, from iron plates | |
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| c. 1500 |
| | | Nanak, the first of the Sikh gurus, takes to the road as a wandering teacher | |
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| c. 1500 |
| | | The first watches, made in Nuremberg, are spherical clocks about three inches in diameter, worn usually on a ribbon round the neck | |
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| c. 1500 |
| | | The first modern lock gates are installed on a canal in Milan, probably designed by Leonardo da Vinci | |
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| c. 1500 |
| | | Faenza becomes the main centre for the production of the Italian tin-glazed earthenware known as majolica | |
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| c. 1500 |
| | | Leonardo argues that fossils in rocks far above the sea imply not the effects of the Flood but a change in the level of an ancient sea bed | |
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| c. 1500 |
| | | The female mamakuna and the male yanakuna are selected in childhood to serve the Inca state | |
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| 1500 |
| | | Portuguese explorer Pedro Cabral, with a fleet of thirteen ships, makes landfall in Brazil | |
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| c. 1500 |
| | | The Inca empire has about 25,000 miles of well-serviced roads, designed for caravans of llamas | |
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| c. 1500 |
| | | The Portuguese establish trading posts in east Africa, on the coast of Mozambique | |
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| c. 1500 |
| | | European diseases bring death on a massive scale to an American population that has no immunity | |
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| c. 1500 |
| | | The Salic law, preventing inheritance of the throne by or through a woman, is by now accepted as a fundamental law of France | |
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| c. 1500 |
| | | In Cuzco's great temple, the sacrifices are usually of llamas, occasionally of humans | |
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| c. 1500 |
| | | Ceramic artists in Italy decorate large majolica dishes with scenes of narrative history, giving this style the name istoriato | |
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