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| 1999 |
| | | The US relinquishes sovereignty over the canal zone to Panama on the last day of the century, as agreed in the 1977 treaty | |
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| 1999 |
| | | Chromosome 22 becomes the first human genome to be fully sequenced, at the Sanger Institute in Cambridge, England | |
|  | Read-out from gene sequencer
Wellcome Photo Library
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| c. 1999 |
| | | It is estimated that during this year the population of the world reached six billion | |
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| 2000 |
| | | Trade unionist Morgan Tsvangirai leads a newly formed party in Zimbabwe, the MDC (Movement for Democratic Change) | |
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| 2000 |
| | | The new Northern Ireland Assembly is suspended because of IRA failure to decommission arms | |
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| 2000 |
| | | The voters in Zimbabwe reject a new constitution enabling the government to acquire land compulsorily without compensation | |
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| 2000 |
| | | The British Home Secretary, Jack Straw, judges Augusto Pinochet mentally incapable to stand trial and returns him to Chile | |
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| 2000 |
| | | Vladimir Putin wins the presidential election in Russia on the first round | |
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| 2000 |
| | | Rap artist Eminem's album The Marshall Mathers LP enters the US charts at no. 1 | |
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| 2000 |
| | | In Zimbabwe's elections, marred by intimidation and violence, Mugabe's party wins 62 and Tsvangirai's 57 seats in the assembly | |
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