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| 1845 |
| | | Edgar Allan Poe publishes The Raven and Other Poems | |
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| 1845 |
| | | New Yorker Alexander Cartwright devises the set of rules that become the basis of the modern game of baseball | |
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| 1845 |
| | | British archaeologist Henry Layard, in his first month of digging in Iraq, discovers the Assyrian city of Nimrud | |
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| 1845 |
| | | English naval officer John Franklin sets off with two ships, Erebus and Terror, to search for the Northwest Passage | |
|  | Carmichael HMS Erebus and Terror in the Arctic (detail)
National Maritime Museum
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| 1845 |
| | | A blight destroys the potato crop in Ireland and causes what becomes known as the Great Famine | |
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| 1845 |
| | | Henry David Thoreau moves into a hut that he has built for himself in the woods at Walden Pond near Concord, Massachusetts | |
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| 1845 |
| | | The expansionist slogan 'Manifest Destiny' is coined by journalist John L. O'Sullivan to emphasize the right of the USA to extend west to the Pacific | |
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| c. 1845 |
| | | With his emphasis on the subjective experience of human Existenz, the Danish philosopher Kierkegaard plants the seed of existentialism | |
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| 1845 |
| | | Escaped slave Frederick Douglass publishes the first of three volumes of autobiograrphy | |
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| 1845 |
| | | US author Margaret Fuller publishes Woman in the Nineteenth Century, an early and thoughtful feminist study of women's place in society | |
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