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| 1492 |
| | | The world's first globe is published by Martin Behaim without showing America, in the very year of Columbus' voyage | |
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| 1493 |
| | | The Nuremberg Chronicle integrates text and pictures in an ambitious history of the world | |
|  | Nuremberg Chronicle
Fotofile CG
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| c. 1495 |
| | | Dürer, the first great artist to tackle the complexities of printing, becomes a master of woodcut and engraving | |
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| c. 1495 |
| | | The type faces known as roman and italic are created in Venice by the printers Nicolas Jenson and Aldus Manutius | |
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| c. 1500 |
| | | The first etchings are printed in Augsburg, from iron plates | |
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| c. 1520 |
| | | Europe's new printing presses make possible the first pamphlet war, spreading instant arguments for and against the Reformation | |
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| 1530 |
| | | German botanist Otto Brunfels publishes Living images of plants, the first serious work of natural history with printed illustrations | |
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| 1560 |
| | | A book to teach good handwriting is published by Gianfrancesco Cresci, with examples engraved on copper plates | |
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| 1569 |
| | | Flemish cartographer Gerardus Mercator publishes a map of the world, using the projection now known by his name | |
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| 1595 |
| | | A year after Mercator's death, his son publishes a bound collection of his maps with the title Atlas, or Cosmographic Meditations | |
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