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| 1472 |
| | Leonardo da Vinci joins the painters' guild in Florence, probably after training with Verrocchio | |
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| c. 1475 |
| | Tommaso Portinari, the Medici agent in Bruges, commissions an altarpiece from Hugo van der Goes for his family church in Florence | |
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| 1478 |
| | A plot by the Pazzi family, with papal connivance, results in the murder of Guiliano de' Medici during high mass in Florence's cathedral | |
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| 1491 |
| | Savonarola, the new prior of San Marco, is a stern critic of both the pope in Rome and the Medici in Florence | |
| | Savonarola Fotofile CG
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| 1494 |
| | Piero de' Medici and his brothers flee from Florence, after a mob ransacks the Medici palace | |
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| 1497 |
| | Savonarola, in the carnival before Lent, urges the people of Florence to throw playing cards and lewd images on a great bonfire of vanities | |
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| 1498 |
| | The Florentine mob, weary of puritanism, attacks the convent of San Marco and drags Savonarola away to be hanged and burnt | |
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| 1501 |
| | Michelangelo begins work in Florence on a tall thin slab of marble, which he transforms into David | |
| | David Michelangelo Fotofile CG
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| 1571 |
| | Roberto di Ridolfi, a Florentine banker, coordinates a scheme to win the English throne for Mary Queen of Scots | |
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| c. 1575 |
| | Soft-paste porcelain, in imitation of true porcelain from China, is successfully created for the Medici in Florence | |
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