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| c. 1500 |
| | | Faenza becomes the main centre for the production of the Italian tin-glazed earthenware known as majolica | |
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| c. 1500 |
| | | Leonardo argues that fossils in rocks far above the sea imply not the effects of the Flood but a change in the level of an ancient sea bed | |
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| c. 1500 |
| | | The female mamakuna and the male yanakuna are selected in childhood to serve the Inca state | |
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| 1500 |
| | | Portuguese explorer Pedro Cabral, with a fleet of thirteen ships, makes landfall in Brazil | |
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| c. 1500 |
| | | The Inca empire has about 25,000 miles of well-serviced roads, designed for caravans of llamas | |
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| c. 1500 |
| | | The Portuguese establish trading posts in east Africa, on the coast of Mozambique | |
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| c. 1500 |
| | | European diseases bring death on a massive scale to an American population that has no immunity | |
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| c. 1500 |
| | | The Salic law, preventing inheritance of the throne by or through a woman, is by now accepted as a fundamental law of France | |
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| c. 1500 |
| | | In Cuzco's great temple, the sacrifices are usually of llamas, occasionally of humans | |
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| c. 1500 |
| | | Ceramic artists in Italy decorate large majolica dishes with scenes of narrative history, giving this style the name istoriato | |
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