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| c. 45,000 years ago |
| | Neanderthals carve a flute from the leg bone of a young bear, in the region that is now Slovenia | |
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| c. 2800 BC |
| | The harp and the lyre are in use as musical instruments in Mesopotamia | |
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| c. 1500 BC |
| | A copper trumpet is in use in Egypt, forerunner of the brass instruments of the orchestra | |
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| c. 500 BC |
| | The followers of Pythagoras discover the mathematical basis of the octave | |
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| c. 250 BC |
| | The organ, using a mechanical device to pump air through a set of musical pipes, is invented in Alexandria by Ctesibius | |
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