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| c. 380 |
| | | Roman legions begin to be withdrawn from Britain, leaving the Celtic population increasingly vulnerable | |
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| 386 |
| | | St Jerome settles in Bethlehem, where his holy women organize a monastery for his residence and a nearby convent for themselves | |
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| 390 |
| | | St Ambrose asserts the authority of the church, refusing communion to the emperor Theodosius in Milan until he does penance for a massacre | |
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| c. 390 |
| | | The church of Santa Pudenziana in Rome begins the great tradition of Christian mosaics | |
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| 393 |
| | | The ancient games at Olympia, with an unbroken tradition of more than 1000 years, are brought to an abrupt end by the emperor Theodosius | |
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| c. 400 |
| | | Niall of the Nine Hostages is the first man to be called king of Ireland, though his direct control does not extend beyond Ulster | |
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| c. 400 |
| | | The Chinese solve the difficult problem of harnessing a horse without strangling it | |
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| c. 400 |
| | | The earlier of the two Talmuds, consisting of commentaries on the Mishnah, is collected by rabbis in Palestine | |
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| c. 400 |
| | | The Yamato clan adapt Shinto to their own purposes, and claim imperial descent from the sun | |
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| c. 400 |
| | | St Augustine reveals that as a young man, studying and teaching in Carthage, he often prayed for 'chastity and continence, but not yet' | |
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