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| 1853 |
| | | Antoinette Brown becomes the first female to be ordained a minister in the USA, in the First Congregational Church in South Butler, NY | |
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| 1853 |
| | | In the expectation of British and French support, the Ottoman sultan declares war on Russia - launching the Crimean War | |
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| 1853 |
| | | The hypodermic syringe with a plunger is simultaneously developed in France and in Scotland | |
|  | Alexander Wood's hypodermic syringe
Wellcome Library, London
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| 1854 |
| | | British and French warships move up through the Straits and enter the Black Sea in support of Turkey | |
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| 1854 |
| | | Robert Schumann throws himself into the Rhine, in an attempt to commit suicide, and spends the last two years of his life in an asylum | |
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| 1854 |
| | | An anti-slavery movement, formed in the USA to oppose the Kansas-Nebraska Act, adopts a resonant name, calling itself the Republican party | |
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| 1854 |
| | | US inventor Elisha Otis dramatically demonstrates his new safety elevator, cutting the rope suspending his platform in New York's Crystal Palace | |
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| 1854 |
| | | The Boers establish the Orange Free State as an independent republic, with its own custom-built constitution | |
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| 1854 |
| | | Commodore Matthew Perry, commanding a powerful US fleet, persuades the Japanese to open their country to western trade – ending their period of isolation | |
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| 1854 |
| | | The controversial Kansas-Nebraska Act passes into law, enabling citizens of these territories to decide whether or not to allow slavery | |
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