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| 1850 |
| | | The slave trade, but not slavery itself, is banned in Washington and the district of Columbia | |
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| 1850 |
| | | Brazil, historically the world's second largest importer of slaves from Africa, finally bans the slave trade | |
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| 1850 |
| | | US president Zachary Taylor dies after a short illness and is succeeded by his vice-president, Millard Fillmore | |
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| 1850 |
| | | The US Congress passes the Compromise of 1850, designed to defuse the growing crisis over slavery | |
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| 1850 |
| | | The Fugitive Slave Act, concerned with the arrest of runaway slaves, is the most contentious part of the Compromise of 1850 | |
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| 1850 |
| | | Nathaniel Hawthorne publishes his novel The Scarlet Letter, in which Hester Prynne is forced to wear the letter A for Adultress | |
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| 1850 |
| | | US Secretary of State John Clayton and British ambassador Henry Bulwer come to an agreement about the building of a canal between the Atlantic and Pacific | |
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| 1850 |
| | | Escaped slave Harriet Tubman makes the first of many dangerous journeys back into Maryland to bring other slaves into freedom | |
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| 1850 |
| | | Jenny Lind, the 'Swedish Nightingale', has a great success touring the USA in a show presented by P.T. Barnum | |
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| 1850 |
| | | A rebellion against the Qing dynasty, led by Christian convert Hong Xiuquan, breaks out in southern China | |
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