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| 1597 |
| | | Dafne is performed in Florence, becoming the first example of a new art form - opera | |
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| 1698 |
| | | A maker of harpsichords in Florence, Bartolomeo Cristofori, develops the piano ('soft') and forte ('loud') feature which leads to the piano | |
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| 1737 |
| | | Florence loses her independence when the last Medici duke of Tuscany dies | |
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| 1820 |
| | | English poet Percy Bysshe Shelley publishes Ode to the West Wind, written mainly in a wood near Florence | |
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| 1846 |
| | | After marrying secretly, the English poets Robert Browning and Elizabeth Barrett go abroad to live in Florence | |
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| 1854 |
| | | Florence Nightingale, responding to reports of horrors in the Crimea, sets sail with a party of twenty-eight nurses | |
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| 1860 |
| | | Florence Nightingale opens a training school for nurses in St Thomas's Hospital, establishing nursing as a profession | |
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| 1862 November |
| | | Under the title Romola, George Eliot's story of Savonarola in Florence begins publication (completed in August 1863) | |
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| 1898 |
| | | The National Consumers' League, headed by Florence Kelley, fights for improved conditions in the US factories making consumer goods | |
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| 1913 |
| | | Leonardo's Mona Lisa is recovered two years after its theft when the thief, Vincenzo Perugia, tries to sell it to the Uffizi Gallery in Florence | |
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