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| 1515 |
| | | Louis XII is succeeded on the French throne by his cousin and son-in-law, Francis I | |
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| 1515 |
| | | The king of France, Francis I, wins a dramatic victory at Marignano and captures Milan | |
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| 1515 |
| | | The Spanish complete the conquest of Cuba and establish the town of Havana | |
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| 1516 |
| | | The death of Ferdinand II results in Spain becoming part of the Habsburg empire, under the rule of Charles V (as Charles I of Spain) | |
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| 1516 |
| | | Catherine of Aragon gives birth to a daughter, Mary, who becomes the only one of her six children to live beyond infancy | |
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| 1516 |
| | | The original ghetto is established as a district to which the Jews of Venice are confined | |
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| 1516 |
| | | Ariosto, in Orlando Furioso, tells of Roland's madness when he is abandoned by the pagan princess Angelica | |
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| 1516 |
| | | Erasmus publishes an influential edition of the New Testament in its original Greek | |
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| 1517 |
| | | The Ottoman sultan, Selim I, captures Cairo and ends Mameluke rule in the middle east | |
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| from 1517 |
| | | From Bosnia to Egypt and Arabia, the Ottoman Turks now rule the largest Muslim empire since the early caliphate - and will frequently use the title of caliph to assert their authority within Sunni Islam | |
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