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| 1493 |
| | | The Nuremberg Chronicle integrates text and pictures in an ambitious history of the world | |
|  | Nuremberg Chronicle
Fotofile CG
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| c. 1495 |
| | | Dürer, the first great artist to tackle the complexities of printing, becomes a master of woodcut and engraving | |
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| c. 1495 |
| | | The type faces known as roman and italic are created in Venice by the printers Nicolas Jenson and Aldus Manutius | |
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| c. 1500 |
| | | The first etchings are printed in Augsburg, from iron plates | |
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| c. 1500 |
| | | The first watches, made in Nuremberg, are spherical clocks about three inches in diameter, worn usually on a ribbon round the neck | |
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| c. 1500 |
| | | The first modern lock gates are installed on a canal in Milan, probably designed by Leonardo da Vinci | |
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| c. 1500 |
| | | The Inca empire has about 25,000 miles of well-serviced roads, designed for caravans of llamas | |
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| c. 1520 |
| | | Europe's new printing presses make possible the first pamphlet war, spreading instant arguments for and against the Reformation | |
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| 1530 |
| | | German botanist Otto Brunfels publishes Living images of plants, the first serious work of natural history with printed illustrations | |
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| c. 1550 |
| | | The tinderbox provides a new way of making fire - with just flint, steel and tinder | |
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