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| 1463 |
| | | The Chimu empire in Peru is conquered by the Incas under the leadership of Pachacuti's son Topa | |
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| 1464 |
| | | After his death in 1464, Cosimo de' Medici acquires the posthumous title pater patriae – father of the fatherland | |
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| 1464 |
| | | Mehmed II and the Ottoman Turks conquer Bosnia, where a large number of noble families convert to Islam | |
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| c. 1465 |
| | | The Sicilian artist Antonello da Messina adopts the Flemish technique of painting in oils | |
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| 1466 |
| | | In the treaty of Torun the Teutonic knights finally cede Prussia to Poland | |
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| 1466 |
| | | The Portuguese settlers on the Cape Verde islands are granted a monopoly on the new slave trade | |
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| 1468 |
| | | Skanderbeg dies and Albania becomes fully absorbed into the Ottoman empire | |
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| c. 1468 |
| | | Jerome van Aken works almost exclusively in his native s' Hertogenbosch, from which he derives the name Hieronymus Bosch | |
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| 1469 |
| | | Thomas Malory, in gaol somewhere in England, compiles Morte d'Arthur – an English account of the French tales of King Arthur | |
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| 1469 |
| | | The Orkneys and Shetlands come into the possession of James III of Scotland with the dowry of Margaret of Denmark | |
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