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| 1470 |
| | The first Italian printing press is set up in Venice, which soon rivals Germany for the quality of its printing | |
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| c. 1476 |
| | Caxton establishes the first English printing press in London, after working in the new trade in Bruges | |
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| 1477 |
| | Ptolemy's concept of the world, with the Atlantic stretching to China and India, is printed in Bologna – fifteen years before Columbus sails west | |
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| 1492 |
| | The world's first globe is published by Martin Behaim without showing America, in the very year of Columbus' voyage | |
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| 1493 |
| | The Nuremberg Chronicle integrates text and pictures in an ambitious history of the world | |
| | Nuremberg Chronicle Fotofile CG
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| c. 1495 |
| | Dürer, the first great artist to tackle the complexities of printing, becomes a master of woodcut and engraving | |
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| c. 1495 |
| | The type faces known as roman and italic are created in Venice by the printers Nicolas Jenson and Aldus Manutius | |
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| c. 1500 |
| | The first etchings are printed in Augsburg, from iron plates | |
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| c. 1520 |
| | Europe's new printing presses make possible the first pamphlet war, spreading instant arguments for and against the Reformation | |
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| 1530 |
| | German botanist Otto Brunfels publishes Living images of plants, the first serious work of natural history with printed illustrations | |
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