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| c. 650 |
| | Thonmi Sambhota, a student of Sanskrit, devises a way of writing Tibetan and produces treatises on Tibetan grammar | |
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| 656 |
| | Othman is assassinated, and Ali wins power as the fourth Muslim caliph - defeating Muhammad's widow Aisha at the 'battle of the camel' near Basra | |
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| 661 |
| | Ali is assassinated and Mu'awiya becomes the fifth Muslim caliph, establishing the Umayyad dynasty | |
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| c. 661 |
| | The emergence of the Shi'a party creates a major schism within Islam | |
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| 664 |
| | The king of Northumbria summons a synod at Whitby to hear the arguments of Roman and Celtic Christians, then opts for Rome | |
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| 670 |
| | The Arabs establish a garrison town at Kairouan, as a base for the conquest of northwest Africa | |
| | Kairouan Photograph Barnaby Rogerson
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| c. 670 |
| | With the entire middle east under their control, the Arabs make Damascus the capital of the Umayyad caliphate | |
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| 674 |
| | A Muslim fleet attacking Constantinople is deterred by the first known use of the Byzantine secret recipe for 'Greek fire' | |
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| 680 |
| | Husayn, the son of Ali, dies at Karbala in a battle against rival Muslims and becomes the most holy of Shi'ite martyrs | |
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| c. 687 |
| | With a victory at Tertry, Pepin II wins effective control over all three Frankish kingdoms | |
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