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| c. 405 |
| | St Jerome, in Bethlehem, completes the Latin translation of the Bible which later becomes known as the Vulgate | |
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| 406 |
| | The Vandals cross the Rhine into Gaul and move into Spain, from which the Visigoths soon push them on into Africa | |
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| 407 |
| | The Roman city of Nîmes is sacked by the Vandals, in an early indication of the gradual loss of Gaul to the Germanic tribes | |
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| 410 |
| | Alaric and the Visigoths enter Rome and plunder the city - the first foreign intruders for eight centuries | |
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| 413 |
| | The Burgundians cross the Rhine and settle round Worms, before moving south to the Savoy region | |
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| c. 413 |
| | Prompted by the fall of Rome to the Visigoths, St Augustine undertakes a great work of Christian philosophy, the City of God | |
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| 418 |
| | The Visigoths, after twenty years of destructive wandering, settle in southwest France as Roman federates | |
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| 431 |
| | A council is convened at Ephesus to consider the theology of Nestorius, which is judged to be heretical | |
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| 431 |
| | Halted by a Roman army in their push southwards, the Franks settle in the Roman province of Belgica, around Tournai | |
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| 439 |
| | Gaiseric captures Carthage and makes it his base for Vandal raids across the Mediterranean | |
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