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| 158 |
| | A new doctor, Galen, is appointed to look after the gladiators at Pergamum | |
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| 161 |
| | Marcus Aurelius, for long the designated heir, becomes emperor on the death of Antoninus Pius | |
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| 165 |
| | The Romans annexe Doura-Europus, giving it its most prosperious period as a frontier town between the Roman and Persian empires | |
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| c. 165 |
| | The bronze equestrian statue of Marcus Aurelius, on the Capitol in Rome, begins a long European tradition of public sculpture | |
| | Marcus Aurelius, equestrian statue, 2nd century AD Fotofile CG
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| c. 170 |
| | Marcus Aurelius is rare among emperors in writing twelve books of philosophical Meditations | |
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| c. 175 |
| | The Han emperor in China has the six main Confucian classics engraved in stone, so that scholars may take rubbings - a first step towards printing | |
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| 177 |
| | On the order of Marcus Aurelius, Christians in Lyons are tortured to death - an instance of persecution unusual at this time | |
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| c. 200 |
| | The potato is cultivated in the Peruvian Andes | |
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| c. 200 |
| | Rabbi Judah ha-Nasi compiles the Mishnah, a six-part digest of the Oral Torah | |
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| c. 200 |
| | The rock tombs of prosperous Petra, now incorporated in the Roman empire, are carved in the cliffs as classical temples | |
| | Petra, the Treasury Fotofile CG
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