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| 1487 |
| | | The Fuggers make their first loan to a Habsburg archduke, beginning a profitable link with the dynasty | |
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| 1487 |
| | | The Inca empire is extended to the north and a second capital is established at Quito | |
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| 1487 |
| | | Boiardo publishes a romantic epic, Orlando Innamorato, about Roland's love for a bewitching princess | |
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| 1487 |
| | | When Henry VII is in Richmond for Christmas, fire breaks out in his lodging and destroys much of the palace | |
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| 1488 |
| | | Bartolomeu Dias, sailing for the king of Portugal, becomes the first European navigator to round the Cape of Good Hope | |
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| 1488 |
| | | On the death of his father, James III, James IV becomes king of Scotland | |
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| c. 1489 |
| | | Leonardo da Vinci begins an unprecedented series of detailed anatomical drawings, based on corpses dissected in Rome | |
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| 1489 |
| | | Venice's annexation of Cyprus completes a useful chain of islands stretching to the eastern Mediterranean | |
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| 1490 |
| | | On the death of Matthias Corvinus, in 1490, the Habsburgs recover Vienna from the Hungarians | |
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| 1491 |
| | | Savonarola, the new prior of San Marco, is a stern critic of both the pope in Rome and the Medici in Florence | |
|  | Savonarola
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